Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice

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概要

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• Interstitial cells of Cajal (ICC) are important regulatory cells generating electrical rhythmicity and transducing neural signals in the gastrointestinal musculature. ICC express the proto-oncogene c-kit, a receptor tyrosine kinase, and can be examined morphologically using the c-Kit antibody. The c-kit gene is allelic with the murine white-spotting locus W, and the c-kit mutation (W mutation) affects various aspects of hematopoietic cells, germ cells, melanocytes, mast cells, and ICC and have been used to reveal its function. To search for a new model that lacks a specific type of ICC, we examined homozygous Wv/Wv black-eyed-white mice that are viable with anemia. Results showed the principal patterns of ICC deficiency were the same between the W/Wv and Wv/Wv mutants. In the stomach of both mice, intramuscular ICC (ICC-IM) were missing and myenteric ICC (ICC-MY) were reduced in number. In the small intestine, the number of ICC-MY was severely reduced in spite of a normal distribution of deep muscular plexus ICC (ICC-DMP). The cecum also exhibited fewer reduced.

• 2007-10-31

著者

• IINO Satoshi

  Department of Morphological and Physiological Sciences, University of Fukui Faculty of Medical Scien

• HORIGUCHI Satomi

  Department of Morphological and Physiological Sciences, University of Fukui Faculty of Medical Scien

• HORIGUCHI Kazuhide

  Department of Morphological and Physiological Sciences, University of Fukui Faculty of Medical Scien

• NOJYO Yoshiaki

  Department of Morphological and Physiological Sciences, University of Fukui Faculty of Medical Scien

• Iino Satoshi

  福井大学 医学部形態機能医科学

• Horiguchi Kazuhide

  福井大学 医学部形態機能医科学

• Horiguchi Kazuhide

  Department Of Anatomy Faculty Of Medical Sciences University Of Fukui

• Horiguchi Kazuhide

  Department Of Morphological And Physiological Sciences University Of Fukui Faculty Of Medical Scienc

• Nojyo Yoshiaki

  Department Of Anatomy Fukui Medical School

• Horiguchi Satomi

  福井大学 医学部形態機能医科学

• Horiguchi Satomi

  Department Of Morphological And Physiological Sciences University Of Fukui Faculty Of Medical Scienc

• Iino Satoshi

  Department Of Anatomy Faculty Of Medical Sciences University Of Fukui

• Iino Satoshi

  Department Of Anatomy Fukui Medical University

• Iino Satoshi

  Department Of Morphological And Physiological Sciences University Of Fukui Faculty Of Medical Scienc

• Nojyo Yoshiaki

  Department Of Morphological And Physiological Sciences University Of Fukui Faculty Of Medical Scienc

• Horiguchi Satomi

  Department Of Morphological And Physiological Sciences University Of Fukui

• Najyo Yoshiaki

  Department of Morphological and Physiological Sciences, University of Fukui Faculty of Medical Sciences

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