Antifungal Potential of Disulfiram
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概要
- 論文の詳細を見る
Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 μg/ml, respectively, and the MIC range is 1-16 μg/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 μg/ml, respectively.
- 日本医真菌学会の論文
- 2007-07-30
著者
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Singhal Smita
Department Of Infectious Diseases New Drug Discovery Research R & D Iii Sarhaul
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Mathur Tarun
Department Of Infectious Diseases New Drug Discovery Research R & D Iii Sarhaul
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Upadhyay Dilip
Department Of Infectious Diseases New Drug Discovery Research (r &d-3) Ranbaxy Research Laborato
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Upadhyay Dilip
Department Of Infectious Diseases New Drug Discovery Research R & D Iii Sarhaul
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Rattan Ashok
Medical Microbiologist And Laboratory Director Caribbean Epidemiology Centre (carec) Paho/who
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KHAN Seema
Department of Infectious Diseases, New Drug Discovery Research, R & D III, Sarhaul
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Khan Seema
Department Of Infectious Diseases New Drug Discovery Research R & D Iii Sarhaul
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