共役オレフィン類のヒドロアミノ化反応触媒の開発を通じて学んだこと : Yale 大学 Hartwig 研究室にて

概要

論文の詳細を見る
Discovery and understanding of late transition metal-catalyzed intermolecular, hydroamination of vinylarenes with various kinds of alkylamines have been performed. Catalysts having palladium, rhodium, and ruthenium as metal center gave hydroamination products with excellent regio selectivity based on the metal feature. In this paper, catalyst development, reaction scope and mechanistic study are briefly summarized for various hydroamination. Palladium catalyst gave Markovnikov product of styrene derivatives with cyclic and acyclic secondary alkylamines. In contrast, rhodium and ruthenium performed <I>anti</I>-Markovnikov hydroamination of vinylarenes to produce various kinds of amines with or without enamine as side product. Finally, catalytic additions of OH bonds of phenols and carboxylic acids across conjugated dienes were achieved by simple palladium catalyst.
社団法人有機合成化学協会の論文
2007-07-01