Estimation of Membrane Permeability and Intracellular Diffusion Coefficients
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概要
- 論文の詳細を見る
We propose a method for estimating membrane permeability and the intracellular diffusion coefficient using pulsed-gradient spin-echo measurement in combination with numerical simulation. The diffusion signal attenuation of leukocytes was measured with 4π2q2(Δ−δ/3) values up to 6000 s/mm2. For numerical simulations, the cell was modeled as a 15×15 μm2 square with various membrane permeabilities and intracellular diffusion coefficients. Minimization of the difference in signal attenuations between the measurement and the simulation enabled estimations of these unknown parameters for the leukocytes. A cell sample of 2.17×108 cells/mL had a membrane permeability and an intracellular diffusion coefficient of 23 μm/s and 8.9×10-4 mm2/s, respectively.
- 日本磁気共鳴医学会の論文
- 2006-03-31
著者
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UENO Shoogo
Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo
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Ueno Shoogo
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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SANO Masato
Department of Urology, Sapporo Medical University School of Medicine
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Sano Masato
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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Sekino Masaki
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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OGIUE IKEDA
Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Toky
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Ogiue Ikeda
Department Of Biophysics And Life Sciences Graduate School Of Arts And Sciences University Of Tokyo
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Ueno Shoogo
Department Of Applied Quantum Physics Graduate School Of Engineering Kyushu University
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