The Antioxidative Effects of Astragalus Saponin I Protect Against Development of Early Diabetic Nephropathy
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概要
- 論文の詳細を見る
It has been known that oxidative stress plays an important role in the development of diabetic nephropathy (DN). The antioxidative effects of Astragalus saponin I (AS I) were studied in vitro and in vivo. In the presence of high glucose and H2O2, the total antioxidative capability, catalase, reduced glutathione, and superoxide dismutase level of rat mesangial cells were significantly decreased, and transforming growth factor β1 (TGF-β1) mRNA level, collagen IV, and laminin level were significantly increased. When compared with those in the high glucose group, these 4 indexes of cells incubated in 2.0 and/or 20 μmol/L of AS I were significantly enhanced, and levels of TGF-β1 mRNA, collagen IV and laminin were statistically decreased. By flowcytomery, percentages of S phase of cells incubated in high glucose and H2O2 were lowered, while those in AS I were increased. Furthermore, the physical behaviors of rats treated with 12 mg/kg of AS I restored with vigor and weight gaining, while the level of HbAlC was significantly reduced. Thus, AS I has antioxidative effects and is a potential compound worth further study because it may prevent the development of DN.
- 社団法人 日本薬理学会の論文
- 2006-06-20
著者
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Qiu Jun
中華人民共和国
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Qiu Jun
Department Of Pharmacology Nanjing Medical University
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Qiu Jun
Department Of Chemistry Fudan University
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Zhang Pei
Department Of Pharmacology Nanjing Medical University
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Jiang Shaojun
Department Of Pharmacology Nanjing Medical University
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YIN Xiaoxing
Department of Pharmacology, Nanjing Medical University
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ZHANG Yindi
Department of Pharmacology, Nanjing Medical University
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YU Junxian
Department of Pharmacology, Nanjing Medical University
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SHEN Jianping
Department of Pharmacology, Nanjing Medical University
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WU Haiwei
Department of Pathogenic Biology, Nanjing Medical University
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ZHU Xiang
Department of Pathogenic Biology, Nanjing Medical University
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Zhu Xiang
Department Of Pathogenic Biology Nanjing Medical University
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Wu Haiwei
Department Of Pathogenic Biology Nanjing Medical University
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Yu Junxian
Department Of Pharmacology Nanjing Medical University
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Zhang Yindi
Department Of Pharmacology Nanjing Medical University
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Yin Xiaoxing
Department Of Pharmacology Nanjing Medical University
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Shen Jianping
Department Of Hematology First Hospital Affiliated To Zhejiang Chinese Medical University
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