Differential Expression of Platelet Glycoprotein Ia/IIa in Taiwan Chinese Corresponds to Glycoprotein Ia Gene Polymorphisms

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概要

• 論文の詳細を見る

• Glycoprotein (GP) Ia/IIa plays a key role in platelet function by acting as a primary receptor for subendothelial collagen, thereby contributing to arterial thrombosis. In this study, we found that the expression level of platelet GPIa/IIa among Taiwan Chinese varies over sixfold and this difference relates either to the GPIa gene 807 C/T dimorphisms or the appearance of BglII restriction sequence within intron G. This is the first study to demonstrate the wide variation of platelet GPIa/IIa density in an Oriental population and its correlation to the GPIa gene polymorphisms. These results provide useful tools for predicting platelet GPIa/IIa density of Chinese.

• 社団法人 日本薬理学会の論文
• 2006-05-20

著者

• Wang Ji-hung

  Division Of Cardiology Buddhist Tzu Chi General Hospital Hualien Taiwan

• Liu Chao-zong

  Department Of Pharmacology College Of Medicine Tzu Chi University

• WANG Yi-Chai

  Department of Pharmacy, Buddhist Tzu Chi Shin Dian General Hospital

• SHAWA Cheng-Kuang

  Department of Public Health, College of Medicine, Tzu Chi University

• LIN Gang-Ling

  Institue of Pharmacology and Toxicology, College of Life Sciences, Tzu Chi University

• Lin Gang-ling

  Institue Of Pharmacology And Toxicology College Of Life Sciences Tzu Chi University

• Wang Yi-chai

  Department Of Pharmacy Buddhist Tzu Chi Shin Dian General Hospital

• Shawa Cheng-kuang

  Department Of Public Health College Of Medicine Tzu Chi University

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