Inhibitory Effect of Zacopride on Cisplatin-Induced Delayed Emesis in Ferrets
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the antiemetic effect of zacopride, a potent 5-HT3-receptor antagonist with 5-HT4-receptor agonist properties, on delayed emesis caused by cisplatin (5 mg/kg, i.p.) in ferrets, compared with granisetron, a selective 5-HT3-receptor antagonist. Multiple intravenous injections of zacopride at 1 mg/kg, a dose that completely inhibited acute emesis caused by cisplatin (10 mg/kg, i.v.), significantly reduced delayed emesis. Granisetron (3.2 mg/kg) also reduced delayed emesis but this failed to reach statistical significance. The present study suggests that a combined 5-HT3-receptor antagonist / 5-HT4-receptor agonist, like zacopride, may be useful against both acute and delayed emesis induced by cancer chemotherapy.
- 社団法人 日本薬理学会の論文
- 2006-05-20
著者
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MATSUI Shigeo
Department of Surgery, NTT West Osaka Hospital
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Mutoh S
Fujisawa Pharmaceutical Co. Ltd. Ibaraki Jpn
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Mutoh Seitaro
Department Of Urology Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Mutoh Seitaro
Department Of Urology Medicinal Biology Research Lab. Fujisawa Pharmaceutical Co. Ltd.
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Matsui Shigeo
Department Of Cardiology Shiga Medical Center For Adult Disease
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Matsui Shigeo
Department Of Urology Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Matsuo Masahiko
Department of Urology, Medicinal Biology Research Lab., Fujisawa Pharmaceutical Co., Ltd.
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YAMAKUNI Hisashi
Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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NAKAYAMA Hiroe
Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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IMAZUMI Katsunori
Department of Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Nakayama Hiroe
Department Of Urology Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Matsuo Masahiko
Department Of Biology Faculty Of Science Konan University
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Matsuo Masahiko
Department Of Urology Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Imazumi Katsunori
Department Of Urology Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Yamakuni Hisashi
Department Of Urology Medicinal Biology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Matsuo Masahiko
Department Of Biology Faculty Of Science Kobe University
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YAMAKUNI Hisashi
Department of Applied Pharmacology, Kyoto College of Pharmacy
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