Unrelated Cord Blood Transplantation Using a Reduced-Intensity Conditioning Regimen without Total Body Irradiation in Two Patients with Multiple Myeloma

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概要

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• Reduced-intensity unrelated cord blood transplantation was performed on two patients (a 55-year-old woman and a 52-year-old man) with multiple myeloma that had progressed after high-dose chemotherapy (melphalan : 200 mg/m2) with autologous stem cell transplantation support. The conditioning regimen consisted of fludarabine (180 mg/m2) and busulfan (8 mg/kg) without total body irradiation. Tacrolimus was administered as a graft-versus-host disease prophylaxis. The engraftments were rapid (day +17 in patient 1 and day +26 in patient 2). Regimen-related toxicity was tolerable and acute graft-versus-host disease (grade I) appeared only in patient 2. Complete donor chimerism continued following the treatment and no disease progression was observed in the succeeding 12 months. These results demonstrate the feasibility and effectiveness of reduced-intensity cord blood transplantation after autologous stem cell transplantation in older patients.

• 日本リンパ網内系学会の論文
• 2005-12-01

著者

• Komatsu Tsunehiko

  Division Of Hematology Department Of Internal Medicine Tsukuba Memorial Hospital

• NAGASAWA Toshiro

  Clinical and Experimental Hematology, Major of Advanced Biomedical Applications, Graduate School of

• Nagasawa Toshiro

  Clinical And Experimental Hematology Graduate School Of Comprehensive Human Sciences University Of T

• KURITA Naoki

  Clinical and Experimental Hematology, Graduate School of Comprehensive Human Sciences, University of

• Kurita Naoki

  Clinical And Experimental Hematology Graduate School Of Comprehensive Human Sciences University Of T

関連論文

• Identification of a Chromosomal Breakpoint and Detection of a Novel Form of an MLL-AF17 Fusion Transcript in Acute Monocytic Leukemia with t(11 ; 17)(q23 ; q21)
• Unrelated Cord Blood Transplantation Using a Reduced-Intensity Conditioning Regimen without Total Body Irradiation in Two Patients with Multiple Myeloma

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