β-ヒドロキシ-α-アミノ酸の不斉合成

概要

論文の詳細を見る
β-Hydroxy-α-amino acids are valuable constituents of complex natural products and medicinally important compounds. For instance, the naturally occurrence β-hydroxyleucine is a representative of this class and has attracted considerable attention as an unusual amino acid constituent of cyclodepsipeptides such as azinothricin, A 83586 C, papuamides, polyoxypeptins and GE 3. As a consequence of the importance of β-hydroxy-α-amino acids in the biological activities as well as their usefulness as synthetic building blocks, a number of useful strategies have been devised for better method of the synthesis of β-hydroxy-α-amino acids. This review summarizes recent progress in asymmetric synthesis of β-hydroxy-α-amino acids.
2005-12-01