Treatment of Chronic Fatigue Syndrome with Antibiotics : Pilot Study Assessing the Involvement of Coxiella burnetii Infection
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概要
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Objective To examine whether Coxiella burnetii (C. burnetii) is involved in chronic fatigue syndrome (CFS), we administered tetracycline antibiotics to subjects with CFS, and followed changes in clinical symptoms, PCR findings, and C. burnetii antibody titers.Patients and Methods The subjects were 8 patients with CFS and 213 with nonspecific complaints such as chronic fatigue and low-grade fever for several months or longer but not meeting the diagnostic criteria for CFS. All were examined for C. burnetii infection by nested PCR and the indirect immunofluorescence test (IF).Results Four CFS patients (the CFS group) and 54 controls [the post-Q fever fatigue syndrome (QFS) group] positive for C. burnetii were treated mainly with minocycline or doxycycline (100 mg/day) for 3 months. After treatment, all 58 patients tested negative for C. burnetii infection. In the CFS group, no significant difference was noted between the mean pre- and post-treatment temperatures or headache scores. Similarly, there was no significant improvement in performance status (PS) scores. In the QFS group, however, mean temperatures and headache scores were significantly decreased after treatment (p<0.001). PS scores were also improved.Conclusion These results suggest the possibility of direct involvement of C. burnetii in the pathological state of CFS to be low, despite the C. burnetii infection rate being high in CFS patients. This is a pilot study and further larger investigations are necessary to confirm our preliminary results.
- 社団法人 日本内科学会の論文
- 2005-12-01
著者
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IKEDA Tadao
Department of Biology, Nihon University School of Medicine
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Matsukawa Yoshihiro
Division of Hematology and Rheumatology, Division of Hematology and Rheumatology, Department of Medi
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Matsukawa Yoshihiro
First Department Of Internal Medicine Nihon University School Of Medicine
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IWAKAMI Etsuko
Department of Legal Medicine, Nihon University School of Medicine
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ARASHIMA Yasutomo
Department of Clinical Pathology, Nihon University School of Medicine
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KATO Kimitoshi
Division of Gastroenterology and Hepatology, Nihon University School of Medicine
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KOMIYA Tomoyoshi
Research Center for Biologicals, The Kitasato Institute
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ARAKAWA Yasuyuki
Division of Gastroenterology and Hepatology, Nihon University School of Medicine
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OSHIDA Shigemi
Department of Legal Medicine, Nihon University School of Medicine
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Arakawa Yasuyuki
Third Department Of Internal Medicine Nihon University School Of Medicine
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Komiya Tomoyoshi
Department Of Research And Development Research Center For Biologicals The Kitasato Institute
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Arashima Yasutomo
Department Of Laboratory Medicine Nihon University School Of Medicine
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Arashima Yasutomo
Department Of Clinical Pathology Nihon University School Of Medicine
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Ikeda Tadao
Department Of Biology Faculty Of Science Toho University:(present)radioisotope Research Institution
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Oshida Shigemi
Department Of Legal Medicine Nihon University School Of Medicine
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Iwakami Etsuko
Department Of Legal Medicine Nihon University School Of Medicine
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Arakawa Yasuyuki
Division Of Gastroenterology And Hepatology Department Of Medicine Nihon University School Of Medici
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Arakawa Yasuyuki
Division Of Gastroenterology And Hepatology Department Of Internal Medicine Nihon University School
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MATSUKAWA Yoshihiro
Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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Matsukawa Yoshihiro
Division of Hematology and Rheumatology, Department of Medicine, Nihon University Itabashi Hospital
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