An Outbreak of Histamine Poisoning after Ingestion of the Ground Saury Paste in Eight Patients Taking Isoniazid in Tuberculous Ward
スポンサーリンク
概要
- 論文の詳細を見る
Objective To determine the cause of outbreak mimicking food poisoning, we studied the toxic polyamine contents of the food and analyzed the clinical characteristics of the affected eight patients.Patients and Methods Eight cases of histamine poisoning which occurred in tuberculous patients after dinner in our hospital were analyzed by clinical and biochemical methods. We examined the contents of four representative toxic polyamines, histamine, putrescine, cadaverine and tyramine, of the each food of the dinner and their serum concentrations of the monoamine oxidase (MAO), one of histaminases, using radioimmunoassay.Results The allergy-like symptoms such as flushing, headache, palpitation, itching, wheezing, dyspnea and diarrhea appeared from 20 minutes to two hours after ingestion in those eight patients taking isoniazid (INH), although the other 378 inpatients had no symptom. The histamine content of the ground saury paste was increased to 32 mg/100 g of food, however, the toxic level of food poisoning is less than 50 mg/100 g of food. All eight patients were taking INH, and their serum concentrations of MAO were decreased.Conclusion We concluded that this accident was the histamine fish poisoning. We speculated that those allergy-like symptoms were due to both the increased histamine in the food made with the saury under poor storage conditions and the patients’ reduced histaminase activities due to INH. We should perceive possible adverse effects depending on the interactions between certain drugs and food.
- 社団法人 日本内科学会の論文
- 2005-11-01
著者
-
Miki Makoto
Department Of Respiratory Medicine Division Of Cancer Control Institute Of Development Aging And Can
-
Okayama Hiroshi
Department Of Respiratory Medicine Japanese Red Cross Sendai Hospital
-
Miki Makoto
Department Of Respiratory Medicine Japanese Red Cross Sendai Hospital
-
ISHIKAWA Tetsuko
Department of Respiratory Medicine, Japanese Red Cross Sendai Hospital
-
Ishikawa Tetsuko
Department Of Respiratory Medicine Japanese Red Cross Sendai Hospital
関連論文
- Transurethral needle ablation of the prostate : An initial Japanese clinical trial
- Establishment of a Cell Line from an Adenocarcinoma of the Lung Producing Carcinoembryonic Antigen (CEA) and CA19-9
- Successful Treatment of a Case with Rapidly Progressive Bronchiolitis Obliterans Organizing Pneumonia (BOOP) using Cyclosporin A and Corticosteroid
- Perirenal Pseudolymphoma: A Case Report
- The possibility of 'de novo' cancer in the prostate
- M1 prostate cancer with a serum level of prostate-specific antigen less than 10ng/mL
- Primary signet-ring cell carcinoma of the urinary bladder inducing renal failure
- Malignant phyllodes tumor of the prostate
- Efficacy of transurethral needle ablation of the prostate for the treatment of benign prostatic hyperplasia
- Newly Developed Ultrasonic Aspirator and Its Application for Endoscopic Surgery
- An Outbreak of Histamine Poisoning after Ingestion of the Ground Saury Paste in Eight Patients Taking Isoniazid in Tuberculous Ward
- Comparison of Visual Laser Ablation of the Prostate (VLAP) with TURP
- Introduction
- Bilateral Peripheral Infiltrates Refractory to Immunosuppressants were Diagnosed as Autoimmune Pulmonary Alveolar Proteinosis and Improved by Inhalation of Granulocyte/Macrophage-Colony Stimulating Factor