THE EFFECT OF MEDICATION ON QUESTIONNAIRE ANALYSIS OF CHILDREN WITH SCHISTOSOMA MANSONI INFECTION IN TANZANIA

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概要

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• The effect of mass treatment on questionnaire results in the diagnosis of schistosomiasis mansoni was examined in 267 school children in an endemic area of Tanzania by Kato-Katz analysis of fecal specimens. The questionnaire asked for information about self-diagnosis, abdominal symptoms, blood in stools, history of wild water contact, stool examination and medication for schistosomiasis, and knowledge of the disease. A logistic regression analysis disclosed a significant association between schistosomiasis and diarrhea (p ? 0.007; odds ratio, 32.0; confidence interval, 2.5 - 403.3) and abdominal enlargement (p ? 0.003; odds ratio, 15.2; confidence interval, 2.6 - 90.1) among 61 children who had no history of medication for schistosomiasis. The sensitivity and specificity of the model were 86% and 64%, respectively. In contrast, no significant correlation was observed either for the 116 treated children, or for all the 267 children after the mass treatment. We conclude, therefore, that for children who had no history of medication for schistosomiasis, the questionnaire for abdominal manifestations provides reliable information on S. mansoni infection. However, once a child takes medication, the questionnaire becomes unreliable. This observation suggests that immunomodulation by anti-schistosomiasis drugs that kill adult worms exerts an effect on the appearance of abdominal manifestations and might explain the ambiguity of clinical symptoms in chronically infested patients, except in terminal cases. Further studies are required to develop a simple, rapid and cost-effective diagnostic method for monitoring S. mansoni infection after medication in local areas without resort to laboratory-based identification of schistosomiasis.

• 日本熱帯医学会,The Japanese Society of Tropical Medicineの論文
• 2005-09-01

著者

• ATAKA Yuji

  School of Policy Studies, Kwansei Gakuin University

• Ataka Yuji

  School Of Policy Studies Kwansei Gakuin University

• Shimada Masaaki

  Research Centre For Tropical Infectious Diseases Institute Of Tropical Medicine Nagasaki University

• KISU TOMOKO

  Research Centre for Tropical Infectious Diseases, Institute of Tropical Medicine, Nagasaki Universit

• SHIRATORI KIYOSHI

  Japan International Cooperation Agency

• CALLYST FRANCIS

  Majengo Health Care Center

• KANEDA EIKO

  Research Centre for Tropical Infectious Diseases, Institute of Tropical Medicine, Nagasaki Universit

• NGOMUO ELISONGUO

  Mawenzi Hospital, Moshi

• SHAYO RICHARD

  Kilimanjaro Agricultural Training Center

• Kaneda Eiko

  Research Centre For Tropical Infectious Diseases Institute Of Tropical Medicine Nagasaki University

• Kisu Tomoko

  Research Centre For Tropical Infectious Diseases Institute Of Tropical Medicine Nagasaki University

• Ngomuo Elisonguo

  Mawenzi Hospital Moshi

• Shimada Masaaki

  Research Center For Tropical Infectious Diseases Institute Of Tropical Medicine Nagasaki University

• francis callyst

  Majengo Health Care Center

• elisonguo ngomuo

  Mawenzi Hospital, Moshi

• richard j.

  Kilimanjaro Agricultural Training Center

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