Inhibition of Benzo(a)pyrene Induced Lung Adenoma by Panax ginseng Extract, EFLA400, in Swiss Albino Mice(Pharmacology)

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概要

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• In the present investigation the chemopreventive action of Panax ginseng extract, EFLA400, in Swiss albino mice has been evaluated. We used a 9-week medium term anticarcinogenicity test model of lung adenomas [Yun et al.]. Lung adenomas were induced by single subcutaneous injection in the subscapular region with 0.02ml of benzo(a)pyrene (BP) (0.5mg suspension in 1% aqueous gelatin) in newborn mice (less than 24h old). Also chromosomal aberrations and micronuclei induction were evaluated in bone marrow cells. These genotoxicity end-points were compared with adenoma incidence at the same dose levels of BP and EFLA400. The oral administration of EFLA400 (10mg/kg body weight) showed significant reduction in number of adenomas and weight of the lungs induced by BP. A significant reduction (p<0.001) in lung adenoma incidence in EFLA400-treated mice was observed as compared to the 68.3±2.96% lung adenoma incidence in BP-alone group. The inhibition rate was 72.05±1.36% in EFLA400-treated group with respect to the reference group (BP-alone group). However, tumor multiplicity was observed as 0.91±0.08 and 0.25±0.01 in BP alone and BP+EFLA400-treated groups respectively. In EFLA400-treated group significantly reduced frequencies of chromosomal aberrations and micronuclei induced by BP were observed. The results of the present investigation suggest the chemopreventive action and antimutagenic effect of EFLA400 in Swiss albino mice induced by BP in newborn mice.

• 公益社団法人日本薬学会の論文
• 2005-11-01

著者

• Yoon Won

  Department Of Electrical And Computer Ajou University

• Kumar Madhu

  Radiation & Cancer Biology Laboratory Department Of Zoology University Of Rajasthan

• Panwar Meenakshi

  Radiation & Cancer Biology Laboratory Department Of Zoology University Of Rajasthan

• Yoon Won

  Department Of Pharmaceuticals And Health Foods Lotte R&d Center

• Kumar Ashok

  Radiation & Cancer Biology Laboratory Department Of Zoology University Of Rajasthan

• SAMARTH Ravindra

  Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan

• Samarth Ravindra

  Radiation & Cancer Biology Laboratory Department Of Zoology University Of Rajasthan

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