Methods for the Preparation of Highly Functionalized Bicyclo[3.1.0]hexane mGluR2/3 Agonists

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概要

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• A few different approaches for the preparation of highly substituted bicyclo [3.1.0] hexane mGluR2/3 agonists are reviewed. Addition and elimination, carbene insertion, S<SUB>N</SUB>2 type cyclization, and application of Trosts asymmetric allylic alkylation (AAA) are methods of choice for the construction of the ring system. Functionalization of the bicyclo [3.1.0] hexane core structure and synthesis of one of the most potent and selective mGluR2/3 agonists, MGS0028, are also reviewed.

• 社団法人 有機合成化学協会の論文
• 2005-11-01

著者

• Hartner Fredric

  Department Of Process Research Merck Research Laboratories

• Yoshikawa Naoki

  Department Of Process Research Merck Research Laboratories

• Yasuda Nobuyoshi

  Department of Process Research, Merck Research Laboratories

• Tan Lushi

  Department of Process Research, Merck Research Laboratories

• YASUDA Nobuyoshi

  Merck Research Laboratories, Process Research Department

• TAN Lushi

  Merck Research Laboratories, Process Research Department

• YOSHIKAWA Naoki

  Merck Research Laboratories, Process Research Department

• HARTNER Frederick

  Merck Research Laboratories, Process Research Department

• Tan Lushi

  Department Of Process Research Merck Research Laboratories

• Yasuda Nobuyoshi

  Department Of Process Research Merck Research Laboratories

関連論文

• P-50 PREPARATION OF HIGHLY FUNCTIONALIZED BICYCLO [3.1.0] HEXANE mGluR2/3 AGONISTS
• Methods for the Preparation of Highly Functionalized Bicyclo[3.1.0]hexane mGluR2/3 Agonists
• A new synthetic method for some pyrazolo[4,3-d]pyrimidines.

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