AIP1, a Water-Soluble Fraction from Artemisia iwayomogi, Suppresses Thymocyte Apoptosis in Vitro and Down-Regulates the Expression of Fas Gene(Pharmacognosy)
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概要
- 論文の詳細を見る
The AIP1 fraction, a small water-soluble fraction purified from Artemisia iwayomogi, was shown to increase antibody production and suppress transplanted tumor cell growth in mice. In order to understand its immuno-modulating activity, we have examined the effect of the AIP1 on mouse thymocytes in vitro. Treatment of mouse thymocytes in culture with the fraction resulted in the suppression of the cell death and the extension of the cell survival. A mouse gene array provided a profile of gene expression change showing the pattern of up- and down-regulated genes by the AIP1 treatment, suggesting that the Fas/FasL-dependent apoptosis pathway might be modulated by the fraction.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Park Joo
Department of Internal Medicine, Chonnam University Medical School
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Youn Hyun
School Of Biotechnology & Biomedical Science And Bio-health Product Research Center Inje Univers
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Ji Hee
School Of Biotechnology & Biomedical Science And Bio-health Product Research Center Inje Univers
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Koo Kyung
School Of Biotechnology & Biomedical Science And Bio-health Product Research Center Inje Univers
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Yeo Hee
School Of Biotechnology & Biomedical Science And Bio-health Product Research Center Inje Univers
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Cheong Seon
Department Of Biology College Of Natural Sciences Kyungpook National University Korea
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Cheong Seon
Department Of Biology College Of Natural Sciences Changwon National University
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HWANG Jung
School of Biotechnology & Biomedical Science and Bio-Health Product Research Center, Inje University
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LEE Nam
School of Biotechnology & Biomedical Science and Bio-Health Product Research Center, Inje University
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OH Gap
Department of Biology, College of Natural Sciences, Changwon National University
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YOON Chun
Department of Biology, College of Natural Sciences, Changwon National University
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Yoon Chun
Department Of Biology College Of Natural Sciences Changwon National University
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Oh Gap
Department Of Biology College Of Natural Sciences Changwon National University
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Park Joo
Department Of Biology College Of Natural Sciences Changwon National University
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Hwang Jung
School Of Biotechnology & Biomedical Science And Bio-health Product Research Center Inje Univers
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Lee Nam
School Of Biotechnology & Biomedical Science And Bio-health Product Research Center Inje Univers
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