Nardostachys chinensis Glycoside Induces Characteristics of Neuronal Differentiation in Rat Pheochromocytoma PC12 Cells(Communications to the Editor)

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概要

• 論文の詳細を見る

• Rat pheochromocytoma PC12 cells undergo neuronal differentiation in response to nerve growth factor. We show here that exposure of PC12 cells to Nardostachys chinensis glycoside induces the outgrowth of neurites, increases the activity of AChE, triggers cell cycle arrest in G1 and enhances the expression of growth associated protein 43 (GAP-43). Both the outgrowth of neurites and the increase in AChE activity are prevented partly by PD98059, a specific inhibitor of MEK1. These results suggest that N. chinensis glycoside induces the characteristics of neuronal differentiation in PC12 cells via the mitogen-activated protein kinase (MAPK)-related signal cascade.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• Yin Fei

  Natural Medicine Research Center Chongqing Technology And Business University

• Zheng Xu

  Natural Medicine Research Center Chongqing Technology And Business University

• LIU Jian

  Natural Medicine Research Center, Chongqing Technology and Business University

• Liu Jian

  Natural Medicine Research Center Chongqing Technology And Business University

関連論文

• Nardostachys chinensis Glycoside Induces Characteristics of Neuronal Differentiation in Rat Pheochromocytoma PC12 Cells(Communications to the Editor)

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