Study of the Absorption of Myo-Inositol Hexakisphosphate (InsP_6) through the Skin(Miscellaneous)

概要

論文の詳細を見る
Recently, some properties of myo-inositol hexakisphosphate (InsP_6) are related to its dermatological use as discolouring agent, on preventing calcinosis cutis or due to its important role on premature aging. Some studies also seem to demonstrate a capacity of InsP_6 to inhibit skin cancer. In this paper, a first study of the absorption of InsP_6 through the skin is developed. Due to the correlation between InsP_6 absorption and its urinary excretion, these last values were used to evaluate this process. It was found that using a moisturizing cream as vehicle, the InsP_6 sodium salt was absorbed at significantly higher amounts than the InsP_6 calcium-magnesium salt. Maximum InsP_6 urinary concentrations were observed approximately at 14 d of 2% InsP_6 topical cream application, and gave 66.35±5.49mg/I urinary InsP_6 when the sodium salt was used and 16.02±2.61mg/I urinary InsP_6 when the calcium-magnesium salt was applied. When the InsP_6 topical cream administration ceased, the InsP_6 urinary excretion fell dramatically approximately during a period of 10d. From these results, it can be deduced that by topical administration InsP_6 can achieve important concentrations in tissues and biological fluids, this demonstrating that it is possible to propose the topic use as a new InsP_6 administration route.
2005-04-01