Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS)(Pharmacology)

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This study was undertaken to elucidate the mechanism of anti-inflammatory action of gentianine, a constituent of Gentiana Macrophylla. The effects of gentianine on lipopolysacharide (LPS)-induced production of pro-inflammatory cytokines were investigated in male Sprague-Dawley rats. For the first time, we found that oral administration of gentianine (10-100mg/kg) suppressed the increases in tumor necrosis factor-α (TNF-α) (ED_<50>, 37.7mg/kg) and interleukin (IL)-6 (ED_<50>, 38.5mg/kg) in the sera from the rats challenged with bacterial LPS (100μg/kg ; i.p.). However, LPS induced production of other interleukins, such as IL-α, was not significantly altered by gentianine. These results suggest that the potential anti-inflammatory action of gentianine might be at least partly based on the suppressed production of TNF-α and IL-6.
社団法人日本薬学会の論文
2005-04-01