Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro(Pharmacology)
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概要
- 論文の詳細を見る
Prostate cancer is the most predominant cancer in men and prostate cancer related death increases every year. Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies reported that aged garlic extract suppresses cancer growth and enhances immune system against cancer. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative effect on prostate cancer cells in vitro. The suppression of cell growth was demonstrated by [^3H]thymidine incorporation assay. Induction of DNA damage was assessed by agarose gel electrophoresis. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 50μM and 100μM concentrations, diallyl disulfide induced DNA damage in PC-3 cells. It is concluded that diallyl disulfide, component of aged garlic extract, inhibits proliferation of prostate cancer cells through the induction of apoptosis.
- 社団法人日本薬学会の論文
- 2005-04-01
著者
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Arunakaran Jagadeesan
Department Of Endocrinology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras
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Aruldhas Maria
Department Of Endocrinology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras
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Vijayababu Marati
Department Of Endocrinology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras
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Vijayababu Marati
インド
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ARUNKUMAR Arumugam
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras
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KANAGARAJ Palaniyandi
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras
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BALASUBRAMANIAN Karundevi
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras
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Kanagaraj Palaniyandi
Department Of Endocrinology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras
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Arunkumar Arumugam
Department Of Endocrinology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras
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Balasubramanian Karundevi
Department Of Endocrinology Dr Alm Pg Institute Of Basic Medical Sciences University Of Madras
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Balasubramanian Karundevi
Department Of Endocrinology Dr. Alm Pg Institute Of Basic Medical Sciences University Of Madras
関連論文
- Chemoprevention of Rat Prostate Carcinogenesis by Diallyl Disulfide, an Organosulfur Compound of Garlic(Pharmacology)
- Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro(Pharmacology)
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