Hypoglycemic and Antihyperglycemic Effect of Gmelina asiatica LINN. in Normal and in Alloxan Induced Diabetic Rats(Pharmacology)

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The hypoglycemic and antihyperglycemic effect of alcoholic extract of root of Gmelina asiatica LINN. (G. asiatica) was investigated in normal and in alloxan induced diabetic rats. The blood glucose levels were measured at 0h and 1, 2, 4, 6, 8 and 16h after the treatment. The alcoholic extract of G. asiatica showed significant (p<0.05) dose dependent percentage blood glucose reduction in normal (25.8% at 100mg/kg, 28.9% at 250mg/kg and 32.4% at 500mg/kg body weight) and in diabetic rats (26.6% at 100mg/kg, 32.1% at 250mg/kg and 48.2% at 500mg/kg body weight) respectively at 6h. The antihyperglycemic effect of G. asiatica was compared with the reference standard drug tolbutamide (40mg/kg).
公益社団法人日本薬学会の論文
2005-04-01