Apoptosis Induced in Human Cell Lines by a Butanol Extract from Chlorophytum comosum Roots

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概要

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• The antiproliferative effects of a n-butanol extract from Chlorophytum comosum (C. comosum) (spider plant) roots was tested in vitro against four human cell lines: HeLa, CCRF-HSB-2, HL-60 and U937 cells. The extract was found to have cell antiproliferative effects against HeLa, CCRF-HSB-2, HL-60 and U937 cell lines, with an IC_<50> value of 6.6, 5.4, 8.7 and 10.2μg/ml, respectively. The dying cells showed characteristics of apoptosis, such as DNA fragmentation, as assessed by DNA electrophoresis analysis and the Terminal deoxynucleotidyl transferase (TdT)-mediated biotin dUTP Nick End-Labeling (TUNEL) method. These results indicate that extract from C. comosum roots can induce apoptosis in human cell lines.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• Ishikawa Satoko

  共立薬科大学

• MOCHIZUKI Masataka

  Division of Organic and Bioorganic Chemistry, Kyoritsu College of Pharmacy

• Mochizuki Masataka

  Tokyo Univ. Of Sci. Fac. Of Pharmaceutical Sciences

• Matsushita Hirohisa

  Bioscience Research & Development Center

• Kuwabara Hiroaki

  Division of Organic and Bioorganic Chemistry, Kyoritsu University of Pharmacy

• Ishikawa Satoko

  Division of Organic and Bioorganic Chemistry, Kyoritsu University of Pharmacy

• Ishikawa Satoko

  Division Of Organic And Bioorganic Chemistry Kyoritsu University Of Pharmacy

• Kuwabara Hiroaki

  Division Of Organic And Bioorganic Chemistry Kyoritsu University Of Pharmacy

• Matsushita Hirohisa

  Bioscience Research & Development Center:division Of Organic And Bioorganic Chemistry Kyoritsu U

• Mochizuki Masataka

  Division Of Organic And Bioorganic Chemistry Kyoritsu College Of Pharmacy

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• IN VITRO METABOLISM OF N, N-DIALKYLNITROSAMINES IN RELATION TO THEIR ACTIVATION
• Apoptosis Induced in Human Cell Lines by a Butanol Extract from Chlorophytum comosum Roots

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