Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents

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概要

• 論文の詳細を見る

• For the construction of new combinatorial libraries, a lead compound was created by replacing the core structure of a hit compound discovered by screening for cytotoxic agents against a tumorigenic cell line. The newly designed compound maintained biological activity and allowed alternative library construction for antitumor drugs.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• Agatsuma Toshinori

  Biomedical Research Laboratories Sankyo Co. Ltd.

• Hayakawa Ichiro

  Lead Discovery Research Laboratories Sankyo Co. Ltd.

• SHIOYA Rieko

  Lead Discovery Research Laboratories, Sankyo Co., Ltd.

• SUGANO Yuichi

  Lead Discovery Research Laboratories, Sankyo Co., Ltd.

• Shioya Rieko

  Lead Discovery Research Laboratories Sankyo Co. Ltd.

• Sugano Yuichi

  Lead Discovery Research Laboratories Sankyo Co. Ltd.

関連論文

• Synthesis and Evaluation of 3-Methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic Acid Ethyl Ester Derivatives as Potent Antitumor Agents

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