An Easy Access to 7-Methyl-2-naphthalenecarbonitrile
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概要
- 論文の詳細を見る
A practical and cost-effective procedure has been developed for the synthesis of 7-methyl-2-naphthalenecarbonitrile, the precursor of the anticoagulant agents YM-60828 or YM-96765. This new route generates the key intermediate in only two steps from readily available 3-cyanopropionaldehyde dimethyl acetal and m-tolualdehyde, without requiring chromatographic purification. The synthesis involves condensation of the cyano derivative with the aldehyde and subsequent cyclodehydration.
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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Yanagisawa Isao
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.
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Yamada Hiroyoshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Matsumoto Yuzo
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.ltd.
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KOSHIO Hiroyuki
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
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ISHIHARA Tsukasa
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
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HIRAYAMA Fukushi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
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Koshio Hiroyuki
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Yanagisawa Isao
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Hirayama Fukushi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Ishihara Tsukasa
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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MATSUMOTO Yuzo
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
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