Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C-Acylation of 2-Pyridone

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概要

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• A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl) benzoic acid, a pair of structural isomers 2-aryl pyrido [2,1-a] isoindole-4,6-diones and 4-aryl 1-methyl-1H-indeno [1,2-b] -pyridine-2,5-diones, as potential inhibitors of tumor cell proliferation, were prepared respectively.

• 公益社団法人日本薬学会の論文
• 2005-01-01

著者

• Wang Shaozhong

  National Laboratory Of Solid State Microstructures And Department Of Physics Nanjing University

• WANG Shaozhong

  Department of Chemistry, Nanjing University

• CAO Liya

  Department of Chemistry, Nanjing University

• SHI Haijian

  Department of Chemistry, Nanjing University

• DONG Yanmei

  Department of Chemistry, Nanjing University

• SUN Jianwei

  Department of Chemistry, Nanjing University

• HU Yuefei

  Department of Chemistry, Tsinghua University

• Cao Liya

  Department Of Chemistry Nanjing University

• Hu Yuefei

  Department Of Chemistry Tsinghua University

• Sun J

  Fudan Univ. Shanghai Chn

• Sun Jianwei

  Department Of Chemistry Fudan University

• Shi Haijian

  Department Of Chemistry Nanjing University

• Dong Yanmei

  Department Of Chemistry Nanjing University

関連論文

• Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C-Acylation of 2-Pyridone
• M_xO_y/SO_4^/Dealuminated Zeolite β(M=Mi, Fe)as Novel Catalysts for Alkylation of Isobutane with 1-Butene

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