Synthesis and Pharmacological Activity of 4-(4'-(Chlorophenyl)-4-hydroxypiperidine) Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A new series of 4-(4'-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2,3 and 5 produced reduction in blood pressure in normotensive rat.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
-
Khan Khalid
Hej Research Institute Of Chemistry International Centre For Chemical Sciences University Of Karachi
-
Perveen Shahnaz
Pcsir Laboratories Complex Off University Road
-
Abdel‐jalil R
Univ. Tuebingen Tuebingen Deu
-
Shah Syed
Abteilung Fur Physikalische Biochemie Des Physiologisch-chemischen Instituts Der Universitat Tubinge
-
VOELTER Wolfgang
Abteilung fur Physikalische Biochemie, Physiologisch-Chemisches Institut der Universtitat Tubingen
-
SAIFY Zafar
HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karac
-
MUSHTAQ Nousheen
HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karac
-
ABDEL-JALIL Raid
Chemistry Department, Faculty of Science, Hashemite University
-
FECKER Miriam
Abteilung fur Physikalische Biochemie des Physiologisch-chemischen Instituts der Universitat Tubinge
-
Saify Zafar
Hej Research Institute Of Chemistry International Centre For Chemical Sciences University Of Karachi
-
Voelter W
Univ. Tuebingen Tuebingen Deu
-
Voelter Wolfgang
Abteilung Fur Physikalische Biochemie Des Physiologisch-chemischen Instituts Der Universitat Tubinge
-
Mushtaq Nousheen
Hej Research Institute Of Chemistry International Centre For Chemical Sciences University Of Karachi
関連論文
- A New and Efficient Approach for the Synthesis of Peptides Containing Aspartylglycyl Sequences
- A New Base-Labile Anchoring Group for Polymer-Supported Oligosaccharide Synthesis
- An Expeditious Synthesis of Optically Pure 1,4,5,6-Tetrahydro-as-Triazines, Fused to the Carbohydrate Skeleton
- Synthesis and Pharmacological Activity of 4-(4'-(Chlorophenyl)-4-hydroxypiperidine) Derivatives
- Structure of Hemocyanin Subunit CaeSS2 of the Crustacean Mediterranean Crab Carcinus aestuarii
- Capillary electrophoresis in clinical chemistry
- Purification and Characterization of a Novel Sialidase from a Strain of Arthrobacter nicotianae