脂質の細胞内転送マシナリーと創薬

概要

論文の詳細を見る
Intracellular transport of cholesterol was monitored with mouse penitoneal macrophages. Efflux of endocytosed cholesterol from lysosome is dependent on pH gradient between lysosomal membranes iand sensitive to C 17 or 20 oxosteroids. The “transport” of cholesterol through lysosomal membranes is specific to cholesterol structure. These indicate that there are some cell machinaries which are rerponsible for intracellular traffics of cholesterol.<BR> We could detect α-tocopherol specific binding protein (transfer protein) in liver cytosolic fraction. This protein stimulates the transfer of α-tocopherol between membranes. The defficiency of this protein causes severe shortage of α-tocopherol in body, resulting in ataxia. This indicates that the protein detected in liver is responsible for recycling of α-tocopherol in body.
1996-09-20