成長期ラットの虚弱脛骨骨幹皮質骨における食餌療法に関する X 線学的骨塩量および病理組織学的研究
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Attention has paid to the studies on association of calcium-contained dietary treatment and bone matrix formation in recent years, considering the problem of low calcium intake in children. To maximize the peak bone mass with the help of dietary treatment is viewed as valuable for matrix formation up to 20 years of age. The present study used rats of 3- and 6-week old, which corresponding to weaning and school childhood years in human beings, to induce bone loss by calcium deficiency and low calcium feeding for 3 weeks. Calcium-balanced dietary treatment of 3 weeks followed immediately, and matrix formation of cortical bone of tibial diaphysis was investigated. The results were as follows. 1. Bone density Of 3-week-old groups, medial cortex showed decreased density in calcium deficiency and low calcium groups (p<0.05) comparing with the control group ; and interosseous cortex showed decreased density in calcium deficiency (p<0.05) comparing with the control group. Of 6-week-old groups, medial cortex showed decreased density in calcium deficiency (p<0.01) and low calcium groups (p<0.05) comparing with the control group ; and interosseous cortex showed decreased density in calcium deficiency and low calcium groups (p<0.01) comparing with the control group. Low calcium groups showed higher density than calcium deficiency groups (p<0.05). 2. X-ray microanalysis of Ca and P Higher calcium concentration was revealed than phosphorus among all the groups of 3 and 6 weeks of age, by area analysis on X-ray microanalysis. 3. Histopathologic findings Of 3-week-old groups, intercellular substance was scanty and bone marrow sparsely scattered in low calcium group, in contrast to those of control group. Of 6-week-old groups, internal and external basal lamellae showed densely thickened, and number of Haversian canals increased dramatically with the canal of comparable size. Recovery was identified significant in such bone structure as cement line and remodeling layer. 4. Hematological findings Endocrinological examination on C-PTH, N-PTH, CT, 1, 25(OH)_2VD_3 showed no significant differences among the control, calcium deficiency and low calcium groups. From the above results, dietary treatment itself could not help with recovery of bone tissue from calcium deficiency in weaning age ; while the restoration and promotion of bone matrix formation were revealed in school childhood, where bone loss from calcium insufficiency had been followed by continuing balanced dietary therapy. The action was thought to be related to the activity of hormones regulating bone metabolism.
- 九州歯科学会の論文
- 1998-10-25
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- 成長期ラットの虚弱脛骨骨幹皮質骨における食餌療法に関する X 線学的骨塩量および病理組織学的研究
- 成長期の虚弱脛骨骨幹皮質骨における食餌療法