成長期の虚弱下顎骨における食餌療法に関する X 線的, 光顕的および超微形態的研究 : 骨基質形成
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概要
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There have scarcely been reports on bone matrix formation after dietary treatment of mandibular bone loss resulting from inadequate calcium intake at growing age. Here we present the study on bone matrix formation of mandible after calcium-containing supplements, for bone loss from calcium deficiency and low calcium feeding, using male Wistar rats of 3 and 6 weeks of age, corresponding to weaning period and school childhood in human beings respectively. I. Body weight Calcium deficiency group showed lower values in 3 weeks of age, compared with control group (p<0.05). No significant difference was revealed between 6-week-old groups, which showed increased values over 3-week group. II. Radiographic bone density Calcium deficiency and low calcium groups showed significantly lower density than control group (p<0.01 and p<0.05 respectively) in 3-week-old groups. No difference was demonstrated significantly among the 6-week groups, which showed higher values than 3-week groups. III. Radiographic microanalysis Calcium was revealed higher in density than phosphorus in area analysis of characteristic radiogram in both 3 and 6 weeks of age. IV. Histopathologic findings 3-week-old As compared with calcium deficiency group, low calcium group showed increased lamellar bone and remodeling layers ; but it was revealed that lamellar bone and osteocytic lacunae decreased significantly, arranged irregularly, and bone marrow cavity was enlarged. 6-week-old Low calcium group showed identical bundle bone structure as in control group, regularly-arranged lacunae, thickened compact bone, and decreased lamellar bone. V. Scanning electronic microscopic findings 3-week-old Collagen fibrils were shown to be scarce, and resorptive zone abundant in calcium deficiency and low calcium group, comparing with control group. 6-week-old Bone formation was revealed more than resorption in low calcium group, with collagen fibrils arranged in regular direction, compared with that in control group. Decreased bone formation was identified where the trabeculae were scarce. VI. Hemotologic findings 3-week-old Calcium deficiency and low calcium groups showed decreased serum calcium compared with control group (p<0.05). 6-week-old As compared with control group, GPT was shown elevated in calcium deficiency and low calcium group (p<0.05); and CPK elevated in low calcium group (p<0.05). No significant difference was found at endocrinological examination in both 3-and 6-week groups. On the basis of these results, it was shown that calcium-containing dietary treatment could not contribute to the bone construction adequately in calcium intake insufficiency circumstances during weaning and schoolchild period.
- 九州歯科学会の論文
- 1998-02-25