Bite plate 使用が MRL-lpr/lpr マウスの顎関節に及ぼす影響について
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概要
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Rheumatoid arthritis (RA) is known as an inflammatory systemic disease that occurs in connective tissue, mostly in the synovial membrane of the joint. The inflammatory symptom may occur non-specifically all over the joints and become polyarthritis. Among these RA patients, 60∿80% have been reported to be temporomandibular joint (TMJ) involvement. With the prevalence of orthodontic treatment today, RA patient will surely increase in our daily practice, but there has been few reports about the influence of orthodontic treatment on the temporomandibular joint of RA patients. The purpose of this study was to explore the influence of bite plate on the TMJ of the mouse with RA. MRL-lpr/lpr (MRL/l) mice with spontaneous polyarthritis were used to serve the purpose in this study and the changes in the condylar cartilage of their mandibles resulting from bite plate were investigated histopathologically. The results obtained in present study are as follows : 1. There was no significant difference between the control group of MRL/l mice and ICR mice. 2. In MRL/l mice group with bite plate installed, the condylar cartilage of mandible showed slight thinning from the first week, and the cellular arrangement of condylar cartilage of mandible became irregular : Thus the increase of both proliferation layer and cartilage layer were recognized. On the other hand, ICR mice group with bite plate installed showed the thickness of proliferation layer increased and of cartilage layer decreased from the first week. 3. In MRL/l mice group with bite plate installed, the findings were similar until the third week ; but from the fourth week, both the proliferation layer and the cartilage layer were found increased. On the other hand, in ICR mice group with bite plate installed, the regularity of cellular arrangement in cartilage layer remained and the increase of thickness in proliferation layer and significant decrease of cartilage layer were found during the second, third and fourth week. 4. Both MRL/l mice group with bite plate installed and ICR mice group had similar histological findings in the eighth week. From these results, there were no significant differences with respect to the histological reaction in the condylar cartilage of the MRL/l mice group and the ICR mice group, except the cartilage healing process in the MRL/l mice group was slightly slower than that in the ICR mice group. Orthodontic treatment appears to be possible for RA patients, if care is taken, even though their TMJ confront with orthodontic force or the resulting changes of muscular function. The results may not be applicable to human perfectly for there are still differences between human and experimental animals. Further studies are still required on this subject.
- 九州歯科学会の論文
- 1997-02-25