成長期骨基質形成におけるメカニカルストレスの影響 : 電子顕微鏡学的検索
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概要
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The influence of different mechanical stress on the growth of metaphysis of tibia was investigated experimentally by electon microscopy. Wister strain rats were subjected to treadmill running 1h/day, 5days/wk for 4wk with a different speed : 10m/min, 30m/min, 40m/min. The results are summarized as follows : 1. Scanning electron microscope findings Among control group and different exercises groups, increase in formation of bone matrix was found in the ascending order of control group, 10m/min speed group 30m/min speed group. In trabeculae, width, bone mass and form of arrangement remarkably increased in the ascending order of control group, 10m/min speed group, 30m/min speed group. As compared with the control group, 40m/min speed group showed wide chondrocyte layers. But trabeculae continuing from subchondral bone formation zone showed active resorption findings and were formed thin, and formation of bone matrix was restrained. 2. Transmission electron microscope findings Among control group and different exercises groups, increase in active type osteoblasts showing active bone formation and osteocytes were seen in the ascending order of the control group, 10m/min speed group, 30m/min speed group. 40m/min speed group in comparison with the control group, active type osteoblasts were showed a decreasing tendency and fibroblast-like osteoblasts in dormancy increased. Osteoid osteocytes and young osteocytes were seen to increase in the ascending order of control group, 10m/min speed group, 30m/min speed group. But, in the case of 40m/min speed group, the number of osteocytes were decresed. Osteoclasts showed various morphology and activation in the ascending order of the control group, 10m/min speed group, and 30m/min speed group. Differentiation and activation of osteoclasts in 40m/min speed group as compared with the control group were restrained On the basis of the foregoing finding, moderate exercise below the threshold level at the growth stage induces activation for various cells and is closely involved in bone matrix formation in the metaphysis of the tibia.
- 九州歯科学会の論文
- 1997-02-25