実験的歯の移動における破骨細胞新生誘導作用について

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概要

• 論文の詳細を見る

• The purpose of this study is to investigate the osteoclast inducing activity in the bone extract from long bone of normal rats and from alveolar bone of untreated and orthodontic appliance installed rats. Bone extract was added to mouse bone marrow culture, and the induced osteoclasts were monitored by counting the number of tartrate-resistant acid phosphatase (TRAP) positive cells and mesuring the area of the pit formed. 1. In long bone extract from the normal rats, the osteoclast inducing activity was recognized. The increase was suppressed by hydroxyurea, an inhibitor of cell proliferation. 2. In alveolar bone extract from the untreated rats, the osteoclast inducing activity was also recognized. The increase in the activity by adding 10^<-6>M PGE_2 was low in alveolar bone extract and high in the long bone extract. 3. When 10 g orthodontic forces was applied at upper incisors for 3 days, the osteoclast inducing activity in the alveolar bone around the incisors increased more than that in untreated bone. The activity of the bone applied the force for 6 or 10 days decreased and became less than that of untreated bone. When 10^<-6>M PGE_2 was added to the culture in order to cancel the influence of the inducing activity of PGE_2 preexisted expected to be contained in the extract, the activity appeared to be the same as that without adding PGE_2. 4. When 100 g orthodontic forces was applied at upper incisors for 3 days, the osteoclast inducing activity in the alveolar bone around the incisors was less than that of untreated bone. The activity of the bone applied the force for 6 or 10 days was less than that of the untreated bone. The activity was not affected by the addition of 10^<-6>M PGE_2. The level of the activity was lower than that of PGE_2 alone. Since the osteoclast inducing activity in the alveolar bone changed in response to the external loading force, this activity may be involved in the bone-remodeling process during orthodontic tooth movement. Excess amount of PGE_2 little affected on the change in the osteoclast activity of the alveolar bone extract during the tooth movement. PGE_2 seemed not to be predominantly related to the activity.

• 九州歯科学会の論文
• 1996-02-25

著者

• 田中 慎彦

  九州歯科大学歯科矯正学講座

• 田中 慎彦

  大学院歯学研究科

• 田中 慎彦

  九州歯科大学歯学研究科歯科矯正学専攻

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