A Case of Therapy-resisutant Idipathic Hypereosinophilic Syndrome with Severe Disseminated Instravascular Coagulation
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概要
- 論文の詳細を見る
Dissaminated intravascular coagulation (DIC) is a rare complication of idiopathic hypereosinophilic syndorome (HES). We report a case of therapy-resistant HES complicated with DIC, in which the sequential profile of vascular endothelial adhesion molecule, eosinophil granule proteins, and several cytokines during clinical course were observed. Serum proteins derived from eosinophil granule and serum soluble vascular cell adhesion molecule 1 had elevated and fluctuated along with the eosinophilia and DIC. The level of serum tumor necrosis factor-α, which stimulates eosinophil attachment to endothelium, was also high in overt DIC. These findings suggest that there may be strong interactions between eosinophils and vascular endothelium and that adhernce of eosinophils to endothelium and production of eosinophil granule proteins may contribute to the development of DIC in HES.
- Yamaguchi University Graduate School of Medicineの論文
- 2005-02-25
著者
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Amaoka Kunio
Hokkaido University
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Seret Bernard
Museum National D'histoire Naturelle Department Systematique Et Evolution Usm Taxonomie Et Coll
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Seret Bernard
Museum National D'histoire Naturelle Department Systematique Et Evolution Usm Taxonomie Et Coll
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