Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach
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概要
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Objective We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia. Methods Detection and quantification of A3243G mutation in mtDNA in the gastric mucosa, oral mucosa, leukocyte, and skeletal muscle were performed. Gastric motility was evaluated by gastric myoelectrical activity on electrogastrography (EGG), and gastric emptying was evaluated by measurement of plasma paracetamol concentration before and after meals. Patients or Materials Four patients with A3243G mutation in the leukocyte mtDNA and gastric symptoms were examined. Results The A3243G mutation was detected at higher percentages in the gastric body (69-94% for mutation; mean, 83%) than in the angle portion (37-82%; mean, 52%), the antrum (40-84%; mean, 57%) or leukocytes (28-52%; mean, 39%), and at slightly higher percentages than in the skeletal muscles (45-87%; mean, 70%) or oral mucosae (52-86%; mean, 69%) in the four patients examined. Abnormal EGGs were observed in the three patients examined. The pre-prandial myoelectrical activities were low in these patients (49% in patient 1, 54% in patient 2, 63% in patient 3; normal >70%). The plasma concentrations of paracetamol were low (3.6 μg/ml in patient 1, 2.4 μg/ml in patient 2, <2.0 μg/ml in patient 3; normal, 7-12 μg/ml). Conclusion Accumulation of mitochondrial A3243G mutation in the stomach is a contributory factor in gastric dysmotility and gastric symptoms in patients with the mutation in their leukocytes.
- 社団法人 日本内科学会の論文
- 2004-12-01
著者
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Kuriyama Masaru
The Second Department of Internal Medicine (Neurology Division), Faculty of Medical Science, Univers
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Kudo Tadashi
Biomedical Imaging Research Center Faculty Of Medical Sciences University Of Fukui
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Kudo Takashi
Biomedical Imaging Research Center University Of Fukui
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Yoneda Makoto
Second Department Of Internalmedicine Faculty Of Medical Sciences Univerisity Of Fukui
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Azuma Takeshi
Frontier Medical Science In Gastroenterology International Center For Medical Research And Treatment
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Azuma Takeshi
Department Of Gastroenterology Kobe University Hospital
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Azuma T
Second Department Of Internal Medicine Fukui Medical School
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Takabatake Satoru
Department of Gerontology, Kanazawa Medical University
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Azuma T
Frontier Medical Science In Gastroenterology International Center For Medical Research And Treatment
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Yoneda Makoto
The second department of internal medicine, faculty of medical sciencies, university of Fukui
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Sahashi Ko
Department of neurology, Aichi medical university
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Kuriyama M
Second Department Of Internal Medicine Faculty Of Medical Science University Of Fukui
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Sahashi Ko
Department Of Internal Medicine Division Of Neurology Aichi Medical University School Of Medicine
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Sahashi Ko
Department Of Neurology Aichi Medical University
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Muramatsu Atsushi
The Second Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Kuriyama Masaru
Second Department Of Internal Medicine Faculty Of Medical Science University Of Fukui
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FUJII Akihiro
the School of Project Design, Miyagi University
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IBI TOHRU
Department of Internal Medicine, Division of Neurology, Aichi Medical University School of Medicine
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OHTANI Masahiro
the Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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NAKAGAWA Hiroto
the Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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KUMANO Takanori
the Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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HAYASHI Koji
the Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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AZUMA Takeshi
the Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui
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Ohtani Masahiro
The Second Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Ibi Tohru
Department Of Internal Medicine Division Of Neurology Aichi Medical University School Of Medicine
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Ibi Tohru
Department Of Neurology Aichi Medical University School Of Medicine
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Nakagawa Hiroto
The Second Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Kumano Takanori
Biomedical Imaging Research Center University Of Fukui
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Azuma Takeshi
Division Of Gastroenterology Department Of Internal Medicine Kobe University Graduate School Of Medi
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Fujii Akihiro
The School Of Project Design Miyagi Univ.
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Takabatake Satoru
Department Of Gerontology Kanazawa Medical University
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Takabatake Satoru
Department Of Internal Medicine Fukui General Hospital
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Fujii Akihiro
The Second Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Azuma Takeshi
The Second Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Hayashi Koji
The Second Department Of Internal Medicine Faculty Of Medical Sciences University Of Fukui
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Yoneda Makoto
The Second Department of Internal Medicine, Division of Neurology, University of Fukui, Japan
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