Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : Structure and Function of Aquaporins

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概要

• 論文の詳細を見る

• The discovery of the water channel aquaporin has greatly expanded our understanding of the regulation of the water permeability of biological membranes. The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders. Eleven mammalian aquaporins have been identified, each with a distinct distribution, and these are selectively permeated by water or water plus glycerol. Aquaporins are suspected in numerous pathological conditions involving fluid transport such as brain edema. Knowledge of aquaporin structure may provide insight into the development of new therapeutics through appropriate drug design.

• 社団法人 日本薬理学会の論文
• 2004-11-20

著者

• Yasui Masato

  Department of Pharmacology, Keio University School of Medicine

• Yasui Masato

  Departments Of Pediatrics And Biological Chemistry Johns Hopkins University School Of Medicine

• Yasui Masato

  Department Of Pharmacology And Neuroscience Keio University School Of Medicine

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