Applications of ^<14>C-AMS for Carcinogen, Pharmaceutical and Nutrient Studies

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概要

• 論文の詳細を見る

• Accelerator mass spectrometry (AMS) is an ultrasensitive measure for tracing <SUP>14</SUP>C labeled molecules in vivo or detecting the biomarker for assessment of carcinogenesis. Basic principles, wide applications and new progresses of bio-<SUP>14</SUP>C-AMS have been presented. It is a state-of-the-art tool for measuring the adduction of biological molecules with xenobiotics, including carcinogens, drugs, agrochemicals, nicotine etc. . We have studied the genotoxicity and proteins adduction of smoking specific nicotine and its nitrosamine derivative NNK since 1994. The successful applications have proven the effectiveness of AMS in assessment of cancer risk, screening of drug toxicity and studies of nutrient uptake. In particular, AMS is characterized by measuring xenobiotics at very low dose levels relevant to human environmental exposure. It is sensitive and precise to an attomole (10<SUP>-18</SUP> mole) of <SUP>14</SUP>C per mg carbon. Although it has some shortcomings, undoubtedly, AMS possesses an evident merit of high sensitivity and will have widespread applications in the biomedical sciences.

• 日本放射化学会の論文
• 2001-12-01

著者

• Liu Yuanfang

  Department Of Applied Chemistry College Of Chemistry And Molecular Engineering Peking University

• WANG Haifang

  Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University

• SUN Hongfang

  Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University

関連論文

• Radiopharmaceutical Chemistry in Peking University (PKU)
• Applications of ^C-AMS for Carcinogen, Pharmaceutical and Nutrient Studies

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