Ca^<2+>-induced Light Adaptation in Retinal ON-bipolar Cells

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概要

• 論文の詳細を見る

• Retinal ON-bipolar cells possess a metabotropic glutamate receptor linked to the control of a cGMP cascade, which functions to generate high synaptic amplification of rod signals under darkadapted conditions. We report that a major component of light adaptation of the rod visual system results from a reduction in gain in synaptic transmission from rods to ON-bipolar cells, initiated by Ca2+-loading when the cGMP-activated channels of the postsynaptic cell open with light. When intracellular Ca2+-buffering was reduced adaptation was induced in ON-bipolar cells by background light too weak to significantly desensitize rods, a property absent in OFF-bipolar cells. Desensitization of ON-bipolar cell flash responses was induced by raising intracellular free Ca2+.

• The Keio Journal of Medicineの論文
• 1999-09-01

著者

• SHIELLS Richard

  Biophysics Unit, Physiology Department, University College London

• Shiells R

  Biophysics Unit Department Of Physiology University College London

• SHIELLS Richard

  Biophysics Unit, Department of Physiology, University College London

関連論文

• Blocking AMPA receptor desensitization prolongs spontaneous EPSC decay times and depolarizes H1 horizontal cells in carp retinal slices
• Ca^-induced Light Adaptation in Retinal ON-bipolar Cells

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