犬糸状虫感染肺における圧流量関係および肺血管抵抗分布

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概要

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• The pressure-flow relationships and the longitudinal distributions of pulmonary vascular resistance in normal and heartworm-infected (HWI) dogs were compared in an isolated, blood perfused preparation. The pulmonary circulation was partitioned into pulmonary arterial, middle, and venous segment based on the concept of a five element lumped model. The pulmonary arterial pressure-flow relationships were found to be non-linear and convex to the pressure axis in both normal and HWI lungs. The pressure-flow relationships of the pulmonary arterial and venous segment were linear and these slopes in the HWI lungs were significantly higher than the normal lungs. The pressure gradient of the middle segment was increased as flow increased at lower flow range, however, it was not increased during higher perfusion range in both lungs. At higher flow, the pressure gradient of the middle segment in the HWI lungs was significantly higher than the normal lungs. These results suggest that the ohmic resistance was almost equal to the sum of the two slopes of the pressure-flow relationships of the pulmonary arterial and venous segment because the pressure gradient of the middle segment was not altered as flow increased during higher perfusion rate. Because the slopes of the pressure-flow relationships of the pulmonary arterial and venous segment were increased with heartworm infection, the ohmic resistance of HWI lungs would be higher than normal lungs. The intercept pressure on the pressure axis of the linear portion of the pulmonary arterial pressure-flow relationship, a critical closing pressure, was regarded as pressure gradient of the middle segment during higher perfusing rate because the intercept pressures of pressure-flow relationships of pulmonary arterial and venous segment were almost equal to zero. Therefore, the critical closing pressure of HWI lungs would be higher than normal lungs. The pulmonary hypertension of filariasis appears to be due to an increase in ohmic resistance and elevated critical closing pressure.

• 社団法人　日本獣医学会の論文
• 2003-09-25

著者

• Takata Masao

  Pathophysiology Research National Children's Medical Research Center

• Miyasaka Katsuyuki

  Pathophysiology Research National Children's Medical Research Center

• Miyasaka Katsuyuki

  Pathophysiology Research Laboratory National Children's Medical Research Center

• Kondo Motoki

  Research Laboratory Of Veterinary Medical Teaching Hospital Nippon Veterinary And Animal Science Uni

• WASHIZU Makoto

  Research Laboratory of Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science Un

• MATSUKURA Yoshihito

  Research Laboratory of Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science Un

• WASHIZU Tsukimi

  Research Laboratory of Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science Un

• Washizu Tsukimi

  Research Laboratory Of Veterinary Medical Teaching Hospital Nippon Veterinary And Animal Science Uni

• Washizu Makoto

  Research Laboratory Of Veterinary Medical Teaching Hospital Nippon Veterinary And Animal Science Uni

• Matsukura Y

  Research Laboratory Of Veterinary Medical Teaching Hospital Nippon Veterinary And Animal Science Uni

• 近藤 元紀

  Research Laboratory of Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University

• 鷲巣 誠

  Research Laboratory of Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University

• 松倉 克仁

  Research Laboratory of Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University

関連論文

• 犬糸状虫感染肺における圧流量関係および肺血管抵抗分布
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