Repeated Streptozotocin Injections Cause Early Onset of Glomerulosclerosis in Mice

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概要

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• Diabetic nephropathy (DN), a major cause of end-stage chronic renal failure, is histologically characterized by glomerulosclerosis. To investigate the molecular mechanisms of DN, it is important to establish a stable model of glomerulosclerosis in mice, because genomic manipulation techniques (such as gene destruction or transgene insertion) are well established in rodent species. In this study, we found that repeated administrations of streptozotocin led to early onset of glomerular sclerotic lesions in C57BL/6 mice, accompanied with renal dysfunction. During the natural course of DN, glomerular endothelial cells decreased at 10 weeks after the start of streptozotocin-injections, whereas myofibroblastic mesangial cells became evident. Our results provide an animal tool to elucidate the molecular mechanisms of DN, for example to investigate vascular pathology in diabetic glomerular diseases.

• 社団法人　日本実験動物学会の論文

著者

• Mizuno (horikawa)

  Division Of Protein Chemistry Institute For Protein Research Osaka University

• Mizuno Shinya

  Division Of Molecular Regenerative Medicine Course Of Advanced Medicine Osaka University Graduate Sc

• Wen Jinhua

  Division Of Molecular Regenerative Medicine Department Of Molecular Regenerative Medicine

• Mizuno Shinya

  Division Of Molecular Regenerative Medicine Department Of Molecular Regenerative Medicine

• Mizuno-Horikawa Yoko

  Division of Protein Chemistry, Institute for Protein Research, Osaka University

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• Repeated Streptozotocin Injections Cause Early Onset of Glomerulosclerosis in Mice
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