Whats new in genodermatoses?

概要

論文の詳細を見る
Recent genetic analysis of the genodermatoses, in particular the palmoplantar kerato-dermas, has identified the important role of proteins involved in the regulation and formation of epi-dermal cell junctions. There are four major types of junction, of which three have been demonstrated to be important in skin, and in which component proteins such as desmoplakin and connexins are mutated in epidermal disease. These are the gap junctions, desmosomes and adherens junctions. These junctions are responsible for cell-cell adhesion and communication, key properties to maintain the normal cellular phenotype and tissue architecture.
The Keio Journal of Medicineの論文
2001-03-01