バンコマイシンの全合成研究 : K. C. Nicolaou 研究室に留学して
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概要
- 論文の詳細を見る
A number of valuable new synthetic strategies, such as the triazene-driven biaryl ether synthesis, have been developed during the total synthesis of vancomycin. Modern catalytic asymmetric reactions were employed for the construction of the required amino acid building blocks, which were then assembled to the appropriate peptide fragments, whose cyclization in the order A-B/C-O-D/D-O-E led to the framework of vancomycin aglycon. Sequential attachment of the required sugar moieties onto a suitably protected aglycon derivative, followed by deprotection, allowed the stereoselective total synthesis of the glycopeptide antibiotic vancomycin.
- 社団法人 有機合成化学協会の論文
- 2002-03-01