グルコースの分子骨格を足場に用いる不斉合成法の開発

概要

論文の詳細を見る
Reaction of racemic biaryldicarboxylic dichloride with methyl 4, 6-O-benzylidene-α-D-glucopyranoside gave methyl 4, 6-O-benzylidene-2, 3-O- [(R) -biaryldicarbonyl] -α-D-glucopyranoside with perfect diastereoselection. This reaction provided a new method of optical resolution of axially- and planar chiral dicarboxylates. Using the methodology, several types of novel ferrocenyl sugars which showed anti-malaria parasite (P. falciparum) activity have been prepared. Ten types of chiral azacrown ethers were synthesized from α-D-glucose and their catalytic property for the asymmetric Michael addition has been investigated; enantioselectivity switching which is dependent on the azacrown ether catalysts has been achieved.
社団法人有機合成化学協会の論文
2002-03-01