Effect of Mild Stress in Mice Latently Infected Pseudorabies Virus

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概要

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• Stress is one of the important factors that induces reactivation of pseudorabies virus (PrV) in latently infected pigs. We established a murine model of latent PrV infection and examined the effects of mild stress treatment in order to demonstrate that this model simulates natural infection in the pig. Latently infected mice excreted PrV from the nasal cavity under stress treatments consisting of restraint, exposure to cold or transport. Similar reactions have been observed upon treatment with acetylcholine and dexamethasone. The present findings demonstrate that these kinds of mild stress reactivate the virus in murine latent infection models in a manner similar to the induction of latent infection in pigs in the field.

• 社団法人　日本実験動物学会の論文
• 2003-10-01

著者

• Mannen Kazuaki

  Institutes Of Scientific Research Oita University

• Mannen Kazuaki

  Institute Of Scientific Research Oita Medical University

• TANAKA Seiichi

  Institute of Scientific Research, Oita Medical University

• Tanaka Seiichi

  Institute Of Scientific Research Oita Medical University

関連論文

• Construction of Human Fab Library and Isolation of Monoclonal Fabs with Rabies Virus-Neutralizing Ability
• Effect of Mild Stress in Mice Latently Infected Pseudorabies Virus
• Pre-exposure immunization against rabies using Japanese rabies vaccine following the WHO recommended schedule

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