Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
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概要
- 論文の詳細を見る
Fourteen chemical agents used in dental practice were assessed for their cell-transforming activity using the Syrian hamster embryo (SHE) cell transformation assay system. The cell-transforming activity was quantitatively assessed by the frequency of morphological transformation (MT) in SHE cells induced by these agents. MT was induced by m-cresol, guaiacol, formaldehyde, sodium hypochlorite, hydrogen peroxide, sodium arsenite, acid fuchsin, and basic fuchsin, but not by p-chlorophenol, p-phenolsulfonic acid, glutaraldehyde, and erythrosine B. Iodine and chlorhexidine exhibited positive and pseudopositive responses, respectively. The chemical agents exhibiting a negative or pseudopositive response neither induced nor enhanced MT even in the presence of exogenous metabolic activation.
- 社団法人 日本薬理学会の論文
- 2003-12-01
著者
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Tsutsui Takeki
Department Of Pharmacology The Nippon Dental University School Of Dentistry At Tokyo
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YAMAGUCHI Fusae
Department of Pharmacology, The Nippon Dental University
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Yamaguchi Fusae
Department Of Pharmacology The Nippon Dental University
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Tsutsui Takeki
Department of Pharmacology, The Nippon Dental University
関連論文
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- Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
- Assessment of Genotoxicity of Dental Antiseptics: Ability of Phenol, Guaiacol, ρ-Phenolsulfonic Acid, Sodium Hypochlorite, ρ-Chlorophenol, m-Cresol or Formaldehyde to Induce Unscheduled DNA Synthesis in Cultured Syrian Hamster Embryo Cells
- Immortalization of normal human gingival keratinocytes and cytological and cytogenetic characterization of the cells
- In vitro chromosome aberration tests using human dental pulp cells to detect the carcinogenic potential of chemical agents
- Induction of mRNA expression of osteogenesis-related genes by guaiacol in human dental pulp cells
- Cytotoxic effect of eugenol on the expression of molecular markers related to the osteogenic differentiation of human dental pulp cells
- Stimulation of anchorage-independent growth of syrian hamster embryo cells by a deproteinized extract of calf blood (solcoseryl).