1,1-Diphenyl-2-picrylhydrazyl Radical-scavenging Active Compounds from Greater Cardamom (Amomum subulatum Roxb.)

概要

論文の詳細を見る
Constituents of the fruits of greater cardamom (Amomum subulatum) Were fractionated into three fractions, the dichloromethane extract, and the ethyl acetate-soluble and water-soluble fractions of the 70% aqueous acetone extract. The ethyl acetate-soluble fraction showed a high radical-scavenging activity against 1, 1-Biphenyl-2-picrylhydrazyl (DPPH). Four compounds were isolated from the ethyl acetate-soluble fraction, and their structures were ascribed to protocatechualdehyde (1), protocatechuic acid (2), 1, 7-bis(3, 4dihydroxyphenyl)hepta-4E, 6E-dien-3-one (3) and 2, 3, 7-trihydroxy-5-(3, 4-dihydroxy-Estyryl)-6, 7, 8, 9-tetrahydro-5H-benzocycloheptene (4) on the basis of spectroscopic evidence. This is the first isolation of these compounds from greater cardamom. In particular, 4 was a new type of cyclic diarylheptanoid. DPPH radical-scavenging activity of these compounds was measured by colorimetric analysis. Compounds 1 and 3 showed stronger activity than such natural antioxidants as a-tocopherol and L-ascorbic acid. Compounds 2 and 4 were comparable to α-tocopherol and L-ascorbic acid.
財団法人学会誌刊行センターの論文
2001-04-01