エイズウイルスの複製に関わる転写因子を阻害する人工化合物の分子設計

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概要

• 論文の詳細を見る

• HF-κB, HIV-EP1 Sp1, and TBP-E1A are transcriptional proteins involved in the long terminal repeat-directed expression of human immunodeficiency virus. Inhibitory effect of eighteen compounds against NF-κB, HIV-EP1, Sp1, and E1A was studied. The compounds could be classified into six types based on the inhibitory profile. Compounds of class A (ent-2, 11, 12, 13) and B (7, 9) are inhibitory against HIV-EP1. Class B compounds are more potent. Class C (14) compound is a Spl inhibitor. Compounds of D class (1, ent-1, 2) and E (5, 6, 8, 10) are inhibitors of both HIV-EP1 and Sp1. Class E compounds are more potent. NF-κB, HIV-EP1, and Sp1 are all inhibited by class F compounds (3, 4). Zinc complexes of class F compounds inhibit NF-κB without affecting zinc finger proteins. Relevant combination of these inhibitors would allow us to inhibit NF-κB, HIV-EP1, and Sp1 in any combinations.

• 社団法人 有機合成化学協会の論文
• 1997-08-01

著者

• 大塚 雅巳

  京都大学化学研究所

• 藤田 美歌子

  東京大学医科学研究所

関連論文

• エイズウイルスの複製に関わる転写因子を阻害する人工化合物の分子設計
• がん遺伝子関連タンパク質を標的としたドラッグデザイン

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