Morphometric Evidence That YM175, a Bisphosphonate, ReducesTrabecular Bone Resorption in Ovariectomized DogsWith Dietary Calcium Restriction

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概要

• 論文の詳細を見る

• We examined mechanisms by which incadronate disodium (YM175) prevented bone resorption in ovariectomized dogs with dietary calcium restriction using the morphometrical method. YM175 (0.01-1.0 mg/kg) was given to ovariectomized dogs for 18 months. Because lumbar bone mineral density remained constant at month 17, we assumed that the trabecular bone resorption rate was equal to the bone formation rate and that wall thickness equaled resorption cavity depth. YM175 decreased both the bone resorption rate per number of osteoclasts and resorption cavity depth of cancellous pockets which were increased in ovariectomized dogs. These results suggest that YM175 reduces bone loss by decreasing the resorbing activity of osteoclasts.

• 社団法人 日本薬理学会の論文
• 1999-03-01

著者

• Shikama Hisataka

  Metabolic Diseases Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouc

• NISHIKAWA Haruko

  Metabolic Diseases Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yaman

• MOTOIE Hiroyuki

  Metabolic Diseases Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yaman

• Motoie Hiroyuki

  Metabolic Diseases Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouc

• Nishikawa Haruko

  Metabolic Diseases Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouc

• O'uchi Naoto

  Metabolic Diseases Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouc

関連論文

• YM116, 2-(lH-Imidazol-4-ylmethyl)-9H-carbazole, Decreases Adrenal Androgen Synthesis by Inhibiting C17-20 Lyase Activity in NCI-H295 Human Adrenocortical Carcinoma Cells
• Morphometric Evidence That YM175, a Bisphosphonate, ReducesTrabecular Bone Resorption in Ovariectomized DogsWith Dietary Calcium Restriction

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