Coronary Artery Diameter Increase Induced by a Phosphodiesterase 5 Inhibitor, E4021, in Conscious Pigs

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概要

• 論文の詳細を見る

• The effects of intravenous infusions of 1, 3 and 10 μg/kg/min of the phosphodiesterase 5 inhibitor, E4021, at 30-min intervals on coronary artery diameter were studied in 8 conscious pigs monitored with a pair of piezoelectric crystals. The highest dose increased the diameter by 2.9±0.5% (P<0.01 vs vehicle) of the baseline diameter, with a significant decrease in mean pulmonary arterial pressure. However, there were no changes in mean aortic pressure and heart rate. Additionally, E4021 significantly prolonged the duration of the diameter increase induced by nitroglycerin. Thus, phosphodiesterase 5 inhibition causes coronary artery diameter increase and produces an amplifying effect with nitroglycerin.

• 社団法人 日本薬理学会の論文
• 1998-05-01

著者

• Adachi Hideyuki

  Cardiovascular Research Unit Tsukuba Research Laboratories Eisai Co.

• NISHINO Mayu

  Cardiovascular Research Unit, Tsukuba Research Laboratories, Eisai Co.

• Nishino Mayu

  Cardiovascular Research Unit Tsukuba Research Laboratories Eisai Co.

関連論文

• Coronary Artery Diameter Increase Induced by a Phosphodiesterase 5 Inhibitor, E4021, in Conscious Pigs

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