The Novel Anti : Rheumatic Drug TA : 383 Has a Macrophage Migration Enhancing Activity

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We have investigated the effect of a novel anti-rheumatic drug, cis-2-(4-chlorophenyl)-4, 5-diphenyl-2-imidazoline hydrochloride (TA-383), on macrophages. TA-383 (≥10-9 M)significantly stimulated rabbit alveolar macrophage (AM)migration, and its migration-stimulatory activity was more potent than those of L-fucose (5 × 10-3 M), lobenzarit disodium, bucillamine (SA-96)and salazosulfapyridine. In addition, TA-383 enhanced the production and/or release of macrophage migration enhancement factor by rabbit spleen cells. In vivo, TA-383 (0.4 mg/kg, p.o.)has suppressive effects on picryl chloride-induced delayed type hypersensitivity and type II collagen-induced arthritis in mice. These results suggest that the anti-rheumatic activity of TA-383 may be exerted through the dispersion of macrophages from inflammatory sites.
社団法人日本薬理学会の論文
1997-06-01