Possible Mechanisms Underlying the Suppression of Gastric Vagal Afferents Due to Ecabapide (DQ-2511), a Gastroprokinetic Agent, in Rats

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概要

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• We examined the implication of a nitric oxide (NO)-guanosine 3, 5-cyclic monophosphate (cGMP)cascade in the suppression of gastric vagal afferents due to ecabapide in anesthetized rats using a standard extracellular method of multi-unit recording. Sodium nitroprusside (SNP, 0.5 mg/kg), an NO donor, depressed the afferent discharge rate of the vagus nerve, like ecabapide (60 μg/kg). On the other hand, N<SUP>G</SUP>-nitro-L-arginine (L-NNA, 5 mg/kg), an NO biosynthesis inhibitor, significantly elevated its discharge rate. Pretreatment with L-NNA completely blocked the action of ecabapide. Atropine (0.05 mg/kg), a competitive antagonist of muscarinic cholinoceptors, showed no effect on the afferent firing. These results suggest that ecabapide may suppress the activation of vagal afferents in gastric inhibitory vago-vagal reflex pathways through the NO-cGMP cascade.

• 社団法人 日本薬理学会の論文
• 1997-05-01

著者

• Niijima Akira

  Department Of Physiology Niigata University School Of Medicine

• Furuhama Kazuhisa

  Tokyo Research And Development Center Daiichi Pharmaceutical Co. Ltd.

• HATANAKA Satoshi

  Tokyo Research and Development Center, Daiichi Pharmaceutical Co., Ltd.

• Hatanaka S

  Tokyo Research And Development Center Daiichi Pharmaceutical Co. Ltd.

関連論文

• Effects of Hoelen on the Efferent Activity of the Gastric Vagus Nerve in the Rat
• The Effect of Glucose and Other Sugars on the Efferent Activity of the Sympathetic Nerves Innervating the Fatty Tissue
• Possible Mechanisms Underlying the Suppression of Gastric Vagal Afferents Due to Ecabapide (DQ-2511), a Gastroprokinetic Agent, in Rats

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