Biphasic Effects of D_3 : Receptor Agonists, 7 : OH : DPAT and PD128907, on the D_1 : Receptor Agonist : Induced Hyperactivity in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Effects of D<SUB>3</SUB>-receptor agonists, 7-OH-DPAT and PD128907, on the D<SUB>1</SUB>-receptor agonist SKF81297-induced hyperactivity in mice were examined. 7-OH-DPAT and PD128907 significantly suppressed the SKF81297-induced hyperactivity at low doses, but significantly potentiated the hyperactivity at high doses. These D<SUB>3</SUB>-agonists alone had no effect on the motor activity. A κ-receptor agonist that reduces dopamine release had no effect on the SKF81297-induced hyperactivity. These results suggest that lower doses of 7-OH-DPAT and PD128907 may negatively influence the D<SUB>1</SUB>-receptor mediated behaviors via post synaptic D<SUB>3</SUB>-receptors. On the other hand, higher doses of these compounds may positively influence these behaviors via D<SUB>2</SUB> or D<SUB>3</SUB>-receptors.
- 社団法人 日本薬理学会の論文
- 1997-03-01
著者
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Tanaka J
Tokyo University Of Marine Science And Technology
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Mori Tomohisa
Drug Discovery Pharmaceutical Research Center Meiji Seika Kaishi Ltd
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MURASE Kenshi
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaishi, Ltd
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TANAKA Jiro
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaishi, Ltd
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ICHIMARU Yasuyuki
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaishi, Ltd
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Ichimaru Yasuyuki
Drug Discovery Pharmaceutical Research Center Meiji Seika Kaishi Ltd
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Murase Kenshi
Drug Discovery Pharmaceutical Research Center Meiji Seika Kaishi Ltd
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